Remember the 'targets' for good control

By keeping to these levels as much as possible (or lower still) you will be doing your best to stop your eyes getting worse. Occasionally by sticking to these targets your retinopathy will improve, even without laser. Review BMJ17   

 

lifestyle

• 30-120 minutes exercise a day ,
• moderate alcohol consumption only,
• avoid obesity if possible,
• balanced diet including
• 9 portions of vegetables or fruit a day (9 for men, 7 for women), Lowers BP
• minimal of animal or 'hard' vegetable fats,
• low salt, see the evidence
  Alcohol should be limited to one drink or unit a day, six days a week (Mukamal 2004). More than this leads to brain damage.
• Oily fish such as sardine, salmon, tuna, trout, at least twice a week (small amounts are fine...not a whole salmon!).
• Fibre and healthy fats in the diet slows down retinopathy. No transfats and minimal saturated fat.
• no  (ultra) processed food   Cell Metab  19   as this puts weight on and leads to inflamation throughout the body.

blood pressure

• generally 130/80 (see graph) or preferably less BMJ 16. Even less if well <120  BMJ17
• (120/75 ..home monitoring)
• 125/75 or less if protein in urine present (115/70.. home monitor)
• ACE inhibitors or Angiotensin Receptor Antagonists unless young/pregnant/very low blood pressure/poorly tolerated
• The lower the better in macular oedema, as long as you feel well.
• An ideal pressure is below 115 (systolic, first number) for healthy people. <120 is is only suitable for new/well diabetes patients 2012. Otherwise slightly higher as above.
• Home monitoring blood pressures should be 10mmHg (systolic) and 5mmHg (diastolic) lower see than these 'clinic' pressures.
• Depression & anxiety increase BP. 

HbA1c

• 48-58 mmol/mol  (6.5%-7.5%) or less (see graph) with very few or preferably no hypos. These (or slightly lower) levels are the best to prevent complications
• <58 mmol/mol (7.5%) for insulin users; <48 mmol/mol (6.5%) if not using insulin and have good health. Problems with intensive control. Target should be adjusted according to health and age. If you are a type 1 patient and cannot achieve good control, you need to checked for other conditions such as coeliac disease (anti-TTG antibodies), addisons, and thyroid.
• If hypos develop, seek expert advice from your diabetes nurse/doctor.
• if your HbA1c is high (say 97mmol/mol / 11%), then the next step may be to achieve 75  (9%)....in other words, and any improvement is helpful, gradually reaching lower levels above.

sudden decrease in HbA1c

• A sudden improvement in control (HbA1c drop of 33 mmol/mol/3% ) will lead to a temporary rapid increase in progression of retinopathy: laser may be needed.
• Good control is important in the longer term, that is after about 2 years. When people who control their diabetes well will be better off after this period. See
• A temporary increase in retinopathy is most common when starting insulin for the first time, especially if the diabetes is very badly controlled when you start the insulin.
• Individual targets Nice 16

cholesterol and statins

• <4.0mmol/l, and statins recommended for most adult patients with diabetes whatever the cholesterol.
• statins are recommended whatever the cholesterol, if well tolerated age>40y Statins reduce retinopathy EJO 20
• A fibrate such as fenofibrate may help if there a lot or exudates.
• LDL <2
• Avoid if pregnant, GFR <15, pancreatitis
• If GFR low but still >15, need a lower dose.

smoking

• smoking   20 a day triples/quadruples retinopathy
• passive smoking may double retinopathy: room-mates inhale at least 25%
• electronic cigarettes are much much safer and probably have a negligible effect on retinopathy debate BMJ 18
• even 'Just one cigarette a day seriously elevates cardiovascular risk ' BMJ18, so it is best to stop completely.

insulin

• type 1 patients and ideally type 2 patients using insulin with significant glucuose fluctuations, glucose sensors are ideal : Freestyle or Dexcom.
• Insulin pumps generally produce better control still, but are harder to use.

education

• everyone with diabetes should attend an education course, Primary Care Trusts are obliged to send you on such a course, but very few patients have ever attended one. If you have not been on one, discuss this with your diabetic team.

sleep apnoea etc

• this contributes to macular oedema and loss of sight (Schwartz, 2006), and many serious problems.
• It is common in diabetes, particularly if you are overweight. Do you have sleep apnoea?
• see 15    Retina18    Retina19 
• https://savvysleeper.org/sleep-and-diabetes/

glucose level

• 5.0-7.2 mmol/l before meals
• <10.0 mmol/l after meals
• no serious hypos
• for patients who test their glucose levels and adjust insulin doses, the new glucose sensor is highly recommended and has transformed the lives of many patients. They are provided on the NHS for type 1 patients. I would recommned then for type 2 pateints using mulitple insulin injections, but they are not funded by the NHS (~£30/week)

Glitazones

• Rosiglitazone and pioglitazone should not be used if there is significant retinopathy, and certainly not if macular oedema is present, as  they increase macular oedema and fluid retention. Case 49.  Lirglutadite and Exenatide are drugs that can be used instead low also lower weight (they are injections.)

hypoglycaemia

• insulin users need to avoid serious hypoglycaemia. Expert help is usually needed if episodes are severe/frequent. See

neuropathy

• basic
• autonomic

issues

• nadequate care BMJ 11.Bleak picture BMJ 18
• www.webmd.com..aging

compliance

• 10% compliance if multiple treatment,
  ? 60% one tablets
  

type 2 at diagnosis

• need a test for Haemochromatosis